{"id":7020,"date":"2016-03-30T06:32:49","date_gmt":"2016-03-30T06:32:49","guid":{"rendered":"http:\/\/blogs.funiber.org\/it\/?p=7020"},"modified":"2016-06-01T11:45:14","modified_gmt":"2016-06-01T11:45:14","slug":"nutraceutici-polifenoli-e-patologie-cardiovascolari","status":"publish","type":"post","link":"https:\/\/www.funiber.blog\/it\/salute-e-nutrizione\/2016\/03\/30\/nutraceutici-polifenoli-e-patologie-cardiovascolari","title":{"rendered":"Nutraceutici – polifenoli e patologie cardiovascolari"},"content":{"rendered":"

Sono tre parole chiave per introdurre un argomento alquanto dibattuto: l\u2019utilizzo, cio\u00e8, di preparati a base polifenolica per i loro numerosi effetti benefici sulla salute cardiovascolare.<\/p>\n

Partiamo definendo correttamente i nutraceutici<\/strong>. Nutraceutica un neologismo che trova origine nella crasi tra nutrizione<\/em> e farmaceutica<\/em> e si riferisce allo studio di alimenti che si pensa abbiamo una funzione benefica sulla salute umana. Gli alimenti nutraceutici sono alimenti funzionali<\/em> o medical foods<\/em> e tra i pi\u00f9 noti i probiotici, gli antiossidanti, gli omega 3 ed omega 6 in genere utilizzati nella prevenzione di patologie cronico-degenerative.<\/p>\n

Recentemente la ricerca scientifica ha focalizzato l\u2019attenzione con studi di intervento nurizionale sugli effetti benefici di prepararti a base di polifenoli sulla salute cardiovascolare.<\/p>\n

I flavan-3 oli<\/strong>, composti peculiari di cacao e t\u00e9 verde, sono stati oggetto di studio per i loro effetti sulla pressione sanguigna e sulla funzione endoteliale trovando conferme in numerose metanalisi. Di contro per\u00f2 l\u2019effetto a lungo termine del flavan-3 oli non \u00e8 ancora chiaro.<\/p>\n

Punto debole di tali studi \u00e8 rappresentato dalla standardizzazione oltre che dalla biodisponibilit\u00e0. In particolare la biodisponibilit\u00e0 pu\u00f2 essere migliorata aggiungendo o mescolando tali composti con matrici lipidiche, come ad esempio lecitina o latte.<\/p>\n

Altro fattore da non trascurare \u00e8 che l’efficacia di trattamenti a base di polifenoli dipende anche dal profilo genotipico individuale. A tal proposito \u00e8 stato dimostrato che i portatori del polimorfismo E4 sul gene ApoE, oltre ad avere una maggiore predisposizione ad un alto rischio cardiovascolare e neurodegenerativo, rispondono in maniera meno efficace a trattamenti nutraceutici e farmacologici.<\/p>\n

Ulteriori studi sono dunque necessari per meglio investigare sia l’aspetto nutrigenetico che nutrigenomico ma si pu\u00f2 intanto affermare che nutraceutici e cibi funzionali a base di polifenoli possono essere utilizzati come terapia aggiuntiva a quella farmacologica.<\/p>\n

Letizia Saturni<\/p>\n

Approfondimenti:
\n– Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study<\/a>
\n– Tom\u00e9-Carneiro J et al., Polyphenol based nutraceuticals for the prevention and treatment of cardiovascular disease: Review of human evidence<\/a><\/em> Phytomedicine. 2015.
\n– Hanson,A.J. et al.,The APOE genotype:modification of therapeutic responses in Alzheimer’s disease<\/a><\/em>. Curr. Pharm. Des 21,114-120, 2015.<\/p>\n","protected":false},"excerpt":{"rendered":"

Sono tre parole chiave per introdurre un argomento alquanto dibattuto: l\u2019utilizzo, cio\u00e8, di preparati a base polifenolica per i loro numerosi effetti benefici sulla salute cardiovascolare.<\/p>\n","protected":false},"author":11,"featured_media":7087,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_newsletter_tier_id":0,"footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[11],"tags":[827,640,463],"jetpack_publicize_connections":[],"yoast_head":"\nNutraceutici - polifenoli e patologie cardiovascolari<\/title>\n<meta name=\"description\" content=\"nutraceutici - polifenoli e patologie cardiovascolari\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.funiber.blog\/it\/salute-e-nutrizione\/2016\/03\/30\/nutraceutici-polifenoli-e-patologie-cardiovascolari\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nutraceutici - 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